Prof. Dr. med. Manigé Fartasch, M.D.

Funktion/Position:
Professor of Dermatology and Allergology since 1991. Since 1988 Head of the Occupational Dermatoses Clinic, the Skin Physiology and Bioengineering Laboratory and of the Laboratory for Electron Microscopy

Board Certifactions:
Dermatologist and Allergologist since 1988

Anschrift/Addresse:
Dermatologische Klinik mit Poliklinik
Hartmannstr. 14
D-91052 Erlangen, Germany

Telefon:
Fax:
Email: manige.fartasch@derma.imed.uni-erlangen.de

Research Experience and Subjects:

• Structure and Function of the Epidermal Barrier
• Bioengineering of the Skin, Irritation, Occupational Dermatoses
• Atopic Eczema
• Histology, Immunohistochemistry and Ultrastructure of the Epidermis
• Pediatric Dermatology, Genodermatosis

Selected References:

• Fartasch M, Vigneswaran N, Diepgen TL, Hornstein OP
  Immunohistochemical and ultrastructural study on histiocytosis X and non-X histiocytoses. J Am Acad Dermatol: 23: 885-892 (1990)
  
  
• Fartasch M, Vigneswaran N, Diepgen TL, Hornstein OP
  Abnormalities of keratinocyte maturation and differentiation in keratosis palmoplantaris striata. Am J Dermatopathol 12: 275-282 (1990)
  
  
• Fartasch M, Bassukas ID, Diepgen TL
  Disturbed extruding mechanism of lamellar bodies in dry non-eczematous skin of atopics. Br J Dermatol 127: 221-227 (1992)
  
  
• Fartasch M, Bassukas ID, Diepgen TL
  Structural relationship between epidermal lipids, lamellar bodies and desmosomes in human epidermis: An ultrastructural study. Br J Dermatol 128: 1-9 (1993)
  
  
• Fartasch M, Ponec M
  Improved barrier structure formation in air-exposed keratinocyte culture systems. J Invest Dermatol 102: 366-374 (1994)
  
  
• Fartasch M, Bassukas ID, Diepgen TL
  Structural relationship between epidermal lipids, lamellar bodies and desmosomes in human epidermis: An ultrastructural study. Br J Dermatol 128: 1-9 (1993)
  
  
• Hüner A, Fartasch M, Hornstein OP, Diepgen TL
  The irritant effect of different metalworking fluids. Contact Dermatitis 31:220-225 (1994)
  
  
• Holleran WM, Ginns EL, Menon GK, Grundmann J-U, Fartasch M, McKinney CE, Elias PM, Sidransky E
  Consequences of ß-glucocerebrosidase deficiency in epidermis: Ultrastructure and permeability barrier alterations in Gaucher disease. J Clin Invest 93: 1756-64 (1994)
  
  
• Fartasch M
  Human barrier formation and reaction to irritation. Curr Probl Dermatol 23: 95-103 (1995)
  
  
• Diepgen TL, Sauerbrei W, Fartasch M
  Development and validation of diagnostic score for atopic dermatitis incorporating criteria of data quality and practical usefulness. J Clin Epidemiology 49: 1031-1038 (1996)
  
  
• Sidransky E, Fartasch M, Metlay LA, Lee RL, Abella S, Gao W, Elias PM, Ginns EI, Holleran WM
  Epidermal Abnormalities may distinguish type 2 from other types of Gaucher disease. Pediatr Res 39: 134-141 (1996)
  
  
• Fartasch M
  The nature of the epidermal barrier: structural aspects. Adv Drug Deliver Rev 18: 273-282 (1996)
  
  
• Fartasch M
  Ultrastructure of the epidermal barrier after irritation. Microsc Res Techniq 38:1-7 (1997)
  
  
• Fartasch M
  Epidermal barrier in disorders of the skin. Microsc Res Tech 38:361-372 (1997)
  
  
• Fartasch M, Schnetz E, Diepgen TL
  Characterization of detergent-induced barrier alterations-effect of barrier cream on irritation J. Invest Dermatol Symp Proc 3: 121-127 (1998)
  
  
• Fartasch M, Williams ML, Elias PM
  Altered lamellar body secretion and stratum corneum membrane structure in Netherton syndrome: differentiation from other infantile erythrodermas and pathogenic implications. Arch Dermatol. 135:823-32 (1999)
  
  
• Reichelt J, Doering T, Schnetz E, Fartasch M, Sandhoff K, Magin AM
  Normal ultrastructure, but altered stratum corneum lipid and protein composition in a mouse model for epidermolytic hyperkeratosis. J Invest Dermatol. 113:329-34 (1999).
  
  
• Fartasch M, Diepgen TL, Kuhn M, Basketter DA
  Provocative use tests in CAPB-allergic subjects with CAPB-containing product.
  Contact Dermatitis41:30-4 ( 1999)
  
  
• Schnetz E, Kuss O, Schmitt J, Diepgen TL, Kuhn M, Fartasch M
  Intra-and inter-individual variations in transepidermal water loss on the face: facial locations for bioengineering studies. Contact Dermatitis. 40:243-7(1999).
  
  
• Sugar M, Schnetz E, Fartasch M
  Does sodium lauryl sulfate concentration vary with time? Contact Dermatitis. 40:146-9 (1999).
  
  
• Fartasch M, Schnetz E, Ennen J, Lanzendörfer G, Diepgen TL
  Charakterisierung der Barriereveränderungen durch repetitive Irritation – Effekt der Barrierecreme H+G 74: 463-468 (1999)
  
  
• Van de Sandt, Roguet JR, Cohen C, Esdaile D, Ponec M, Corsini E, Barker C, Fusenig N, Liebsch M, Benford D, Brugerolle de Fraissinette A, Fartasch M
  The use of human keratinocytes and human skin models for predicting skin irritation. The report and recommendation of ECVAM workshop 38. ATLA 27: 723-743 (1999)
  
  
• Fartasch M, Abeck D, Werfel T, Diepgen TL, Schmid-Ott G, Ring J, Gieler U
  Current status of the interdisciplinary model project "Neurodermatitis Education for Children and Adolescents"]. Hautarzt. 2000 May;51(5):299-301.
  
  
• Gerdsen R, Stockfleth E, Uerlich M, Fartasch M, Steen KH, Bieber T
  Papular palmoplantar hyperkeratosis following chronic medical exposure to arsenic: human papillomavirus as a co-factor in the pathogenesis of arsenical keratosis? Acta Derm Venereol. 2000 Jul-Aug;80(4):292-3.
  
  
• Elias PM, Fartasch M, Crumrine D, Behne M, Uchida Y, Holleran WM
  Origin of the corneocyte lipid envelope (CLE): observations in harlequin ichthyosis and cultured human keratinocytes. J Invest Dermatol. 2000 Oct;115(4):765-9.
  
  
• Schnetz E, Diepgen TL, Elsner P, Frosch PJ, Klotz AJ, Kresken J, Kuss O, Merk H, Schwanitz HJ, Wigger-Alberti W, Fartasch M
  Multicentre study for the development of an in vivo model to evaluate the influence of topical formulations on irritation. Contact Dermatitis. 2000 Jun;42(6):336-43.
  
  
• Mahler V, Fischer S, Fuchs T, Ghannadan M, Valent P, Fartasch M, Kraft D, Schuler G, Valenta R
  Prevention of latex allergy by selection of low-allergen gloves. Clin Exp Allergy. 2000 Apr; 30(4):509-20.
  
  
• Jürgen Bauer, Friedrich A. Bahmer, Jürgen Wörl, Winfried Neuhuber, Gerold Schuler, Manigé Fartasch
  A strikingly constant ratio exists between Langerhans cells and other epidermal cells in human skin.
  A stereological study using the optical disector method and the confocal laser scanning microscope.
  J Invest Dermatol. 116:313-318 (2001).
  
  
• Schnetz E, Fartasch M
  Microdialysis for the evaluation of penetration through the human skin barrier - a promising tool for future research? Eur J Pharm Sci.12:165-174 (2001).