Research Experience and Subjects:
MAJOR INTEREST
Immune pathogenesis of autoimmune bullous diseases (ABD; pemphigus vulgaris, bullous pemphigoid) - Characterization of human autoreactive T cells in ABD
- ELISPOT assay to monitor autoreactive T cells in ABD
- In vivo-mouse model of pemphigus vulgaris
- Epitope specificity and subclass of autoantibodies in ABD
Immune pathogenesis of cutaneous drug exanthems
- Characterization of drug-specific peripheral and cutaneous T cells
- Phenotype and function of drug-specific T cells in patients and normals
T cell recognition of haptens (metals)- Phenotype and specificity of metal-specific peripheral and cutaneous T cells
SPECIAL CLINICAL INTERST- Allergology (including atopic dermatitis)
- Autoimmune bullous skin diseases
- Cutaneous autoimmune diseases (lupus erythematodes, scleroderma, dermatomyositis, psoriasis)
- Vasculitides
- Phototherapy
- Chronic (autoimmune) urticaria
Selected References:
Hertl M, Bohlen H, Jugert F, Boecker C, Knaup R, Merk HF
Predominance of epidermal CD8+ T lymphocytes in bullous cutaneous reactions caused by beta-lactam antibiotics.
J. Invest. Dermatol. 101:794-799, 1993
Hertl M, Merk HF
Metalle: Chrom. In Wichmann H.E. et al. (Hrsg.): Handbuch der Umweltmedizin, Kapitel VI-3.
Ecomed, Göttingen, S. 1-8, 1994
Hertl M, Jugert F, Merk HF
CD8+ dermal T cells from a sulfamethoxazole-induced bullous exanthem proliferate in response to drug-modified liver microsomes.
Br. J. Dermatol. 130:215-220, 1995
Hertl M, Neckers L, Katz SI
Inhibition of IFN-gamma-induced ICAM-1 expression on human keratinocytes by phosphorothioate oligodeoxynucleotides is the consequence of antisense-specific and antisense non-specific effects.
J. Invest. Dermatol. 104:813-818, 1995
Hertl M, Asada H, Katz SI
Murine epidermal Langerhans cells do not express the low affinity receptor for immunoglobulin E, FCepsilonRII (CD23).
J. Invest. Dermatol. 106:221-224, 1996
Hertl M, Amagai M, Sundaram H, Stanley JR, Ishii K, Katz SI
Recognition of desmoglein 3 by autoreactive T cells in pemphigus vulgaris patients and normals.
J. Invest. Dermatol. 110:62-66, 1998
Haase C, Büdinger L, Borradori L, Yee C, Merk HF, Yancey K, Hertl M
Detection of IgG autoantibodies in the sera of patients with bullous pemphigoid and pemphigoid gestationis: ELISA studies utilizing a baculovirus-encoded form of the extracellular domain of BPAG2.
J. Invest. Dermatol. 110:282-286, 1998
Hertl M, Karr RW, Amagai M, Katz SI
Heterogeneous MHC II restriction pattern of autoreactive desmoglein 3-specific T cell responses in pemphigus vulgaris patients and normals.
J. Invest. Dermatol. 110:388-392, 1998
Büdinger L., Borradori L., Yee C., Eming R., Ferencik S., Grosse-Wilde H., Merk H.F., Yancey K, Hertl M
Identification and characterization of autoreactive T cell responses to bullous pemphigoid (BP) antigen 2 in patients with BP and HLA-DQß1*0301 positive normals.
J. Clin. Invest. 102:2082-2089, 1998
Hertl M.
Ansätze zur Klassifikation kutaner Vaskulitiden anhand immunologischer Charakteristika.
Z. Hautkr. 73:660-668, 1998
Hertl M
Molecular characterization of autoantibodies in pemphigus. In Conrad K., Humbel R.L., Meurer M., Shoenfeld Y und Tan E.M. (Hrsg.): Pathogenic and diagnostic relevance of autoantibodies.
Pabst Science Publishers, Berlin, 1998
Hertl M, Büdinger L, Christophoridis S, Yancey K, Borradori L
Serum IgA- and IgG-autoantibodies targetting bullous pemphigoid antigen 2 in a patient with bullous IgA/IgG disease
Br J Dermatol. 140:750-752, 1999
Riechers R, Grötzinger J, Hertl M
HLA class II restriction of autoreactive T cell responses in pemphigus vulgaris and potential applications for a specific immunotherapy.
Autoimmunity 30:183-196, 1999
Büdinger L, Hertl M
Immunological mechanisms in hypersensitivity reactions to metal ions: an overview.
Allergy, in press
|
